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J., Jirakulaporn, T., Muslin, A
Cereblon-based PROTAC 26 (DYR684) induced rapid, potent and selective UPS-dependent degradation of the DYRK1 protein, resulting in effective suppression of the DYRK1 pathway, superior to that observed with classical type 1 DYRK1 inhibitors
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The exact role of ROS in the cell is not clear ( KRAS G12D mutation promotes the accumulation of H 2 O 2 , but not superoxide or hydroxyl radicals, in pancreatic cancer cells
