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Synergistic effects of sGC activators and organic nitrate donors were observed, suggesting enhanced activity during sexual arousal.[19,73] Further studies have shown that BAY41-2272 enhances nitrergic relaxation responses in the anococcygeus muscle of streptozotocin diabetic rats, a property not observed after treatment with sildenafil.[75] These suggests that sGC activation may be more efficacious than PDE5I in the treatment of diabetes-induced ED and in ED related to cavernous nerve injury during radical pelvic surgery