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Moreover, there is a requirement for a thorough evaluation of safety and immunogenicity for all the NP-based gene delivery systems during the clinical trials

Transfection of NOS2 into tumor cells resulted in more aggressive tumor phenotype in vivo , although in vitro proliferation of transfected cells was reduced [56]

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A skin permeation test was conducted by applying BV-NE for up to 12 hours, revealing increased permeability with higher BV content in the formulations