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The BAY1187982 targeting FGFR2 to deliver auristatin-based payloads, showed poor tolerability in a phase I trial, leading to termination of this study [430]

Inflammation is a complex, multi-pathway biological response, and many peptides are studied for how they interact with inflammatory signaling networks

Biological systems are constantly exposed to reactive oxidants from external sources as well as those generated internally, which can be seen as a trade-off for the benefits of oxygen metabolism

This indicates that while DSIP may have a tendency to reduce infarct size, the effect was not robust enough to be considered statistically significant under the experimental conditions

Even when injected systemically into abdominal fat, the peptide appears to concentrate at injury sites