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To generate DIDO and RBM15 SPOC-deleted cell lines, two gRNAs targeting the flanking region of the SPOC domain (DIDO: 5-GGGTCGTGTCTCCCTCTGGA-3 and 5-CCAAGAATTATATTCGGACG-3

(2) F Bes, W Hofman, J Schuur, and C Van Boxtel (1992) Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients

Treating true deficiency can improve deficiency-related symptoms (including anemia-related fatigue and neurologic issues) (see the NIH ODS Vitamin B12 fact sheet )

M.HayhoeA.et al

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