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Netotic cell death or NETosis consists of the release of granular enzymes to the nucleus, followed by histone citrullination, chromatin decondensation, nuclear envelope disruption, release of NETs and cell death.12 However, under some conditions, neutrophils releasing NETs remain viable.13,14 This is usually associated with release of mitochondrial DNA, rather than nuclear DNA.12 RIPK3/MLKL-dependent lytic death may also result in NET generation.15 Macrophages may also release ETs, called METs and undergo METosis.16 Molecular mechanisms of ferroptosis Ferroptosis is a caspase-independent form of cell death characterized by massive lipid peroxidation at the plasma membrane and/or subcellular compartments such as mitochondria, endoplasmic reticulum or lysosomes7,1719 (Fig