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Nearly half of the bacteria comprising the human gut microbiome are unable to produce NAD + de novo and rely on NAD + precursors available in the environment for their metabolic functions 59,60

H and E and MF stained sections obtained from right sides of both groups, showed that 3 (30%) cases in group 1 and one (11.1%) case in group 2 were of epidermal type (showing increased density of melanin deposition in the basal and supra basal layers)

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