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Inhibition of autophagy-related protein 7 enhances anti-tumor immune response and improves efficacy of immune checkpoint blockade in microsatellite instability colorectal cancer

Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC

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The role of different cell death pathways in T2D has also been intensively investigated in knock-out mouse models, mice lacking Caspase-8 in -cells were protected from in vivo models of type 1 and type 2 diabetes, but with aging, these mice gradually developed hyperglycemia and a concomitant decline in -cells mass, confirming that several different cell death pathways may play a role in T2D [161]