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Separation of the extracts was performed using a synergi Hydro-RP column (2.0 100 mm, 2.5 mm, Phenomenex) with a binary solvent system consisting of 10 mM tributylamine adjusted with 15 mM acetic acid in water (mobile phase A) and methanol (mobile phase B)

Caffeine-free.

[15] Ghebre YT, et al

In contrast, pharmacologic options such as psychostimulants or bupropion show only modest benefits, with mixed efficacy and notable side effects, underscoring their limited role

Here, we summarize current evidence supporting ketotherapy in HF, emphasizing ketone metabolism in the failing heart, metabolic and non-metabolic therapeutic effects, and mechanisms of ketotherapy in HF, involving the dynamics within the mitochondria