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Furthermore, the results of either single or combined intervention will be less promising in far-advanced conditions with established damage, such as neurodegenerative disorders or cancers

Similarly, histone deacetylase (HDAC) inhibitors such as trichostatin A or entinostat may reverse the transcriptionally repressive states established in DTP cells, restoring sensitivity to initial anticancer treatments (Sharma et al., 2010

This three-part logic two independent stimulatory pathways plus reduced inhibition is why the combination is described as more than additive

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Chen X, Ren F, Hesketh J et al (2012) Reactive oxygen species regulate the replication of porcine circovirus type 2 via NF-B pathway