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Interestingly, this region of NACB (Supplementary Fig

Regardless of the mechanisms of cholesterol enrichment, VSMCs compared to macrophages are inefficient at lysosomal processing and trafficking of cholesterol (152,153) and express much less ABCA1(154), which all contribute to impaired cholesterol efflux (155)

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The clinical difference is significant when therapeutic concentration, not just supplementation, is the goal

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