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Description
The de novo biosynthesis of sphingolipids, catalyzed by serine palmitoyltransferase, connects serine and mitochondrial alanine metabolism to membrane lipid diversity, a mechanism that could be exploited to induce tumor cell death under metabolic stress, such as in an amino acid-deprived microenvironment [126]

Dosch SF, Mahajan SD, Collins AR

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Misfolded proteins are retained and refolded in the ER, and terminally misfolded proteins are retrotranslocated to the cytosol, and degraded by the ubiquitinproteasome system 3,4

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