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3 Results 3.1 Vitamin B12 measurements From January 2016 to December 2023, a total of 84 million vitamin B12 measurements were obtained from both public and private healthcare systems in Brazil (Figure 1A)

This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases