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But if any of the following apply to you, your glutathione needs are likely elevated: Chronic digestive issues (IBS, IBD, SIBO, Candida overgrowth) Chronic fatigue or poor sleep Mood symptoms: anxiety, depression, brain fog Chronic infections or a history of immune dysfunction Significant toxin or alcohol exposure Heavy training or high athletic output Metabolic issues (obesity, blood sugar dysregulation) Neurological symptoms (tinnitus, cognitive decline) Older age

Mano J, Kanameda S, Kuramitsu R, Matsuura N, Yamauchi Y (2019) Detoxification of reactive carbonyl species by glutathione transferase tau isozymes