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As the rate-limiting enzyme, -BBD shows predominant expression in hepatic, renal, and cerebral tissues (14)

If you experience inadequate response after 1216 weeks at a therapeutic maintenance dose (typically 1015 mg weekly) despite good adherence and lifestyle modifications, consult your healthcare provider to assess for secondary causes, verify proper administration technique, and consider dose optimization or alternative treatment strategies

29 Interestingly, aberrant histone Kla emerges in osteoporosis pathogenesis

some patients require a lower dose of 50 mg/kg/day due to the side effect of fishsmelling body odour resulting from the drug