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Furthermore, the use of GLP-1 receptor agonists and metformin was associated with a reduction in adverse COVID-19 outcomes compared to other antidiabetic medications, with GLP-1 receptor agonists showing a probability of 25% and metformin a probability of 28% [62]

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Trx1(SH) 2 catalyzes denitrosylation of caspase3 nitrosylated at Cys163, whereas Trx1SNO prevents apoptosis by transnitrosylating caspase3 at the same cysteine residue and induces oncogenic cell transformation [134, 136-138]
