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There is also a trial specifically testing whether retatrutide prevents heart attacks and strokes (TRIUMPH-3, 1,800 people), and a head-to-head trial comparing retatrutide directly against tirzepatide (the active ingredient in Zepbound) under identical conditions (NCT06662383, 800 patients)

NFPS (ALX5407) administered to rats in a maximal electroshock threshold (MEST) model showed positive effects, increasing the seizure threshold with doses ranging from 1.0 to 32 mg/kg (p.o.) (Kalinichev et al

Available at: (Accessed January 5, 2023)

doi: 10.1093/ajcn/68.2.380