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This is due to the possibility that more glycine and serine may be needed to properly catabolize the extra methionine, unintentionally leading to a shortage in these amino acids

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Six months of consistent use is the earliest point where a meaningful assessment can be made

Early warning signs of Vitamin B12 deficiency often include persistent fatigue and weakness, brain fog, memory and concentration issues, a smooth or sore tongue (glossitis), pale or yellowish skin, and tingling sensations in hands or feet

Pharmacol Rev 64, 10041026