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Comprehensive safety studies spanning six months in rats (up to 100 mg/kg/day) and nine months in cynomolgus monkeys (up to 50 mg/kg/day) revealed no adverse findings, with NOAEL reaching the highest applied dosages

A full blood count may reveal macrocytic anaemia (enlarged red blood cells) with elevated mean corpuscular volume (MCV), though this finding is not specific to B12 deficiency and can occur in liver disease independently

Reviews referencing personal health outcomes are summarized editorially

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Regular follow-up appointments should include assessment of patient response, monitoring for adverse effects, and evaluation of the need for dose adjustments