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The mechanisms by which LA reduces liver fat content in HFD animals may be related to suppressing oxidative stress and lipid peroxidation, improving mitochondrial dysfunction, inhibiting insulin resistance, and regulating some related factors or genes (such as ROS-scavenging enzyme genes) to inhibit excessive fat synthesis in the liver

[166] combined porous iron oxide nanoagents (PION)-mediated promoting photothermal therapy (PTT) with CRYBG3 long noncoding RNA (lncRNA)-mediated gene therapy, where PIONs were used as a magnetic nanoagent for magnetic resonance imaging (MRI) and photoacoustic imaging (PAI), and a high cancer cell killing effect was observed in vitro and in vivo

These programs allow for flexible learning while providing the expertise necessary to manage drug safety challenges effectively

Drugs 78 , 13711376 (2018)

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