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Metformin has also been shown to inhibit the calcium-dependent absorption of the vitamin B12IF complex at the terminal ileum

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Nevertheless, studies utilizing more specific biomarkers of vitamin B 12 status, including measures of holo-transcobalamin and methylmalonic acid, have shown more consistent results and a trend towards associations between poor vitamin B 12 status and faster cognitive decline and increased risk of Alzheimers disease (82-86)