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In addition, Shc3 activates the -catenin/T-cell factor (TCF) pathway by interacting with the cytoplasmic components of -catenin, which reduces -catenin degradation and increases the expression of MDR1 (multidrug resistance 1) in HCC, resulting in multidrug resistance [137]
PubMed, Martnez, Rger Marcelo, et al
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