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Dosage for gut issues leaky gut, IBS symptoms, NSAID-related damage is typically 250500 mcg once or twice daily , taken on an empty stomach

doi: 10.1080/13543784.2018.1528225

PMC 1475692

The implications of this effect are not well understood

The kynurenine (KYN) pathway (KP) is of particular importance because it is inducted by systemic low-grade inflammation in peripheral tissues, producing metabolites that are neuroactive (i.e., modulating glutamatergic and cholinergic neurotransmission), neuroprotective, or neurotoxic
