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A cross-sectional study in women found that low levels of IGF-1 were associated with poor knee extensor muscle strength, slow walking speed, and difficulty with mobility tasks [1]

Zambuto et al., 2019

Additionally, oxidative changes can deactivate enzymes and structural proteins, limiting cell activity

observed a significant decrease in TPO-Ab levels in clinical hypothyroidism patients, but not in subclinical cases (50)
