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Starting at very low doses and increasing in small increments allows the most gradual cardiovascular adaptation possible

Since oxidative stress increases the chance of spontaneous mutations, it is possible that this can trigger mutations that make cells more vulnerable to dysfunction

PMID 15797461

Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade

To prevent anti-tumor immunity from transitioning into an immunosuppressive response when the number of ferroptotic cells reaches a certain threshold in the TME, it is necessary to inhibit the activity of immune cells such as natural killer (NK) cells and T cells