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Reprod Fertil Dev 28:72331 Cobin RH (2005) AACE position statement on metabolic and cardiovascular consequences of PCOS

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Elevated plasma TMAO concentrations predict incident CVD risks in multiple clinical cohorts (47, 914), and both animal models with microbial transplantation (4, 15) and various studies on mice and humans with raised TMAO have revealed mechanistic and prognostic links between microbial TMAO production and both atherosclerosis and thrombosis, as well as chronic kidney disease and heart failure (46, 12, 13, 1618)

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