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The phase III LITESPARK-005 trial demonstrated that in patients with advanced ccRCC previously treated with ICIs and anti-angiogenic therapy, belzutifan improved PFS and ORR compared with everolimus, without new safety signals (Powles et al., 2025)

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Experiments performed in differentiated SH-SY5Y neuroblastoma cells have shown that exposure to PS-NPs downregulates expression of the CI subunit NDUFB8, leading to diminished basal and maximal oxygen consumption rates alongside increased proton leakagefurther confirming mitochondrial CI dysfunction 32

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