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Although restricted to animal studies, the KD is related to several pathways in metabolic syndrome and cancer, including increased 5 adenosine monophosphate-activated protein kinase (AMPK) activity, inhibition of the mTOR/AKT pathway, 134 lowering the serum ratio of insulin-like growth factor/IGF-binding protein 3 135 and increasing peroxisome proliferator-activated receptor- coactivator-1 expression (a master mitochondrial metabolic regulator that can increase mitochondrial biogenesis)

Dinehart, MD, dermatologist and MOHs surgeon with Arkansas Dermatology, Little Rock, Arkansas, who presented Whats New and Hot in Derm Oncology, at Winter Clinical Dermatology Conference 2022

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For other neurodegenerative diseases like ALS and MS, the evidence for the therapeutic value of KD or KS are limited, yet promising

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