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At day 90, 5058% of patients in the DFO group have favorable outcomes, much higher than those in the placebo group (31%), suggesting that iron chelating therapy reduces systemic iron overload and may provide long-term benefits for patients with acute stroke

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Modulation of HIF-1 and its upstream and downstream genes may contribute to the pathological processes of angiogenesis, inflammation, and complications such as calcinosis in DM patients (185, 189)

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