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Box plots display min and max values (whiskers), median values (solid line) and interquartile range (upper/lower box)

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Furthermore, using redox-sensitive GFP2 (roGFP2) 9,34,35 as a tool for functional analysis of glutaredoxins, we determined that the inactive monothiol glutaredoxin AtGrxS15 from Arabidopsis thaliana 36 is able to utilize glutathione disulfide (GSSG) but not GSH as a substrate

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The clinical progression of AD is typically divided into three stages: preclinical, mild cognitive impairment (MCI), and dementia