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However, at high concentrations, when RNS levels exceed the capability of its detoxification in the biological system, serious damage to cells may occur [147, 148] due to inhibition of mitochondrial respiratory function by competing with O 2 for interaction with cytochrome oxidase [149] and via nitrative/nitrosative stress [150, 151]

Protective effect of pantothenic acid in kainic acid-induced status eilepticus and associated neurodegeneration in mice

La acetil-L-carnitina puede ceder su grupo acetilo directamente a la coenzima A dentro de la mitocondria, formando acetil-CoA y entrando al ciclo sin pasar por las vas previas

After one week of levocarnitine therapy (3 doses), all patients had trough concentrations between 54 and 180 mol/L (normal 40-50 mol/L) and concentrations remained relatively stable or increased over the course of the study

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