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422 Two large cross-sectional studies using detailed QST profiling found greater thermal insensitivity in painful than painless DPN, suggesting more advanced small fiber dysfunction

While this observational data has limitations and does not establish causation, the mechanistic basis for the difference is plausible: synthetic progestins like medroxyprogesterone acetate bind progesterone receptors with different affinity and also carry partial androgenic and glucocorticoid activity, whereas micronized progesterone behaves more selectively [5]

Gene-editing approaches (TALED, DdCBE) encounter barriers related to delivery efficiency and off-target risks

Antidepressant effect of taurine in diabetic rats