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7.2.1 Non-monotonic dose-response relationships 7.2.1.1 Mechanistic understanding of NMDR effects Many EEDs exhibit non-monotonic dose-response curves where low-dose exposure produces greater biological effects than high-dose exposure ( 7.2.2 Synergistic and antagonistic interaction networks 7.2.2.1 Real-world mixture toxicology Current research predominantly examines single-EED toxicity, while human populations experience simultaneous exposure to complex chemical mixtures