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doi:10.1083/jcb.200908164 pmid:19951898 Ishii I, Ye X, Friedman B, Kawamura S, Contos JJ, Kingsbury MA, Yang AH, Zhang G, Brown JH, Chun J (2002) Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3

Luevano-Contreras 2013)

Additionally, protein expression of the two most significant proteins present in cartilage's extracellular matrix, COL2 and COLXI, increased

Nat Rev Drug Discov 1:463469 Lizarraga D, Gaj S, Brauers KJ, Timmermans L, Kleinjans JC, van Delft JHM (2012) Benzo[a]pyrene-induced changes in MicroRNAmRNA networks

Additionally, alanine is reported to be significantly increased with metformin monotherapy and combined with sulfonylurea, and branched-chain amino acids (valine, leucine, and isoleucine) are increased with metformin therapy (t Hart et al., 2018b)