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Many patients with treatment resistant depression who supplement their SSRIs with methylfolate report improvements in the efficacy of their antidepressants (4)

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Neurological symptoms often develop gradually and may include: Paraesthesia : tingling or 'pins and needles' sensations, typically starting in the feet and hands Numbness : reduced sensation in the extremities, which may affect balance and coordination Burning pain : particularly in the feet, often worse at night Weakness : muscle weakness and difficulty walking Balance problems : unsteady gait and increased fall risk due to proprioceptive impairment Cognitive changes : memory problems, confusion, difficulty concentrating, and mood disturbances Haematological signs may accompany neurological symptoms and include fatigue, weakness, pallor, and shortness of breath due to megaloblastic anaemia

However, preclinical studies indicate its safety profile and potential efficacy in supporting memory, combating cognitive decline, and addressing weight-related health issues