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The first ED pilot study published in 2010 used six LI-ESW sessions in 20 men who were non-responders to PDE5 inhibitors (PDE5i)

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The peptide directly activates IGF-1 receptors on target tissues including skeletal muscle, neurons, fibroblasts, and satellite cells, triggering powerful anabolic cascades through mTOR/PI3K-Akt pathway stimulation without prolonged systemic exposure

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