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Future Directions and Perspectives It would be interesting to investigate whether GSH supplementation or its depletion ameliorates or aggravates hyperglycaemia- or chronic alcohol-mediated oxidative stress and injury in liver, respectively, and to what degree do the GSH-modulating agents affect the damage due to the parent toxins, i.e

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doi: 10.1038/emm.2017.36 151 MagouzFIMahmoudSAEl-MorsyRAAParayBASolimanAAZaineldinAIet al

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