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Oxidative stress appears to represent a central mechanistic pathway linking molecular signalling alterations with structural cardiac pathology

15, Issue 2, Article 66).

Compounds used for cytotoxicity studies Pharmaceutical-grade cisplatin (catalog # PHR1624), oxaliplatin (catalog # PHR1528), carboplatin (catalog # PHR3417), and doxorubicin hydrochloride (catalog # D1515) were purchased from Sigma-Aldrich

In the initial report, the main positive effect of TR is that returning female Long-Evans rats to a control diet late in life restored reproduction at ages when controls were all postreproductive just as with DR