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As one of the most common skin diseases, acne affects more than 80% of adolescents and young adults globally ( 9, 10 )

(7) More specifically, MOTS-c's actions may involve the upregulation of TGF-/Smad pathway-related genes, including TGF-1, TGF-2, and Smad7, suggesting a pivotal role of this pathway in MOTS-c mediated osteogenic differentiation

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For patients who are naturally B12 deficient, more frequent injections about once a month may be ideal