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Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier

13 GSH is synthesized via a two-step enzymatic pathway and can be regenerated from GSSG by GSH reductase using NADPH

doi: 10.1021/jf050384i 13

al eludirlas gracias a la sustitucin Glu3Arg y la extensin N-terminal de 13 aminocidos, Long R3 IGF-1 evita ese secuestro y la rpida depuracin, manteniendo concentraciones activas mucho ms tiempo

Amelioration of methotrexate-induced enteritis by melatonin in rats