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The Cys synthase binds to the STAS domain and reduces the activity of the transporter

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Paudel et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 113.Jeon Y.H., Park Y.H., Lee J.H., Hong J.H., Kim I.Y

The results from this study may reveal an important basis underlying the gender-associated differences in the longevity and the susceptibility to certain age-related diseases, and also further suggest that the decreased synthesis, which is mainly due to the down regulation of GCL gene expression, may be responsible for the age-associated decline in GSH content