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Additionally, TAMs release interferon-gamma (IFN-), which has been reported to enhance lipid peroxidation and ferroptosis by inhibiting SLC7A11 expression

Currently available histological data indicate a dramatic restoration of tyrosine hydroxylase (TH) staining in the substantia nigra (SN) following six weeks of ip Dihexa treatment, and three months of Dihexa treatment results in nearly 100% recovery of SN TH staining(see Figure 32 of Example 4)

Vitamin D deficiency has been linked to mood disorders independently

Nevertheless, given that clearing senescent cells in peripheral tissues has systemic benefits, including the reduction of systemic inflammation, we cannot rule out the possibility that D+Q in the periphery may positively impact the brain (113)