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Sterile water has no preservative, so once the seal is punctured, it can easily become contaminated with bacteria

Biologically plausible domain of applicability All the key events described should be conserved among animal species, suggesting that the AOP may also have relevance for amphibians, reptiles, birds and and invertebrates with sexual reproduction

Oxysterols can incorporate into membranes, altering lipid raft structure and thereby modulating SNARE complex function and vesicle release probability, affecting glutamate and GABA release (Chamberlain et al., 2001

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