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Contraindications Pregnancy and lactation: individual case reports suggest safety during pregnancy (de Bruyn 2015), however data which mainly include in vivo studies (Xi 2008) are insufficient

HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise
This mechanism is confirmed by the finding that TNF- receptor-associated JNK activation is inhibited by administration of antioxidant compounds

doi: 10.3390/antiox11010062
