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Finally, a C-terminal receptor binding domain, consisting of a series of repeating oligopeptides, is thought to bind to as yet unidentified receptors on target cells ( Fig 1A ) 21,22 Intoxication of host cells with TcdA or TcdB is proposed to occur via an ABCD model (A, biological activity

While genetic and environmental determinants are well recognized, diet constitutes a modifiable factor capable of shaping immune regulation, inflammatory pathways, and gut microbiota compositioncentral mechanisms in autoimmune disease pathogenesis

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In addition, an animal model with high TMAO serum levels created by supplementing choline, TMAO, or fecal transplantation is required to verify whether TMAO affects the AF matrix in the rapid atrial pacing AF model

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