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A bioactive collagen peptide trial reported 38% improvement in activity-related pain and 39% improvement in resting pain after 5g/day for 12 weeks

This mechanistic reading is consistent with the clinical pattern seen in semaglutide MASH trials, where steatohepatitis resolution tracks closely with the magnitude of weight loss

Otterbein LEBFH, Alam J, Soares M, Tao Lu H, Wysk M, Davis RJ, Flavell RA, Choi AM: Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

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