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doi: 10.1016/j.bcp.2019.113728 128 GottliebEArmourSMHarrisMHThompsonCB

*Correspondence: Michel Vignes, [email protected] Roussel, [email protected] This article was submitted to Cellular and Molecular Mechanisms of Brain-aging, a section of the journal Frontiers in Aging Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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This selfsustaining state of central hyperexcitability, capable of outlasting the initial peripheral trigger, forms a key pathophysiological basis for a wide spectrum of chronic pain conditions [62]