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These findings position mtNOS1 as an actionable target in overcoming therapy resistance
It is therefore tempting to speculate that defects in the interaction between SOD1, Rac1, and alsin 2 influence redox signaling at the endosomal level
Di Cairano ES, Davalli AM, Perego L, Sala S, Sacchi VF, La Rosa S, Finzi G, Placidi C, Capella C, Conti P, Centonze VE, Casiraghi F, Bertuzzi F, Folli F, Perego C
In these assays, CuCl 2 alone showed no activity up to 250 M, whereas Cu 3 -TC-Py consistently produced IC 50 values in the 10-30 M range and Cu 3 -TC-Thio in the 30-60 M range
