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Activation of NF-B promotes cancer progression by inducing various genes responsible for cancer cell survival, proliferation, and metastasis, and interacts with multiple cancer-associated pathways such as PI3K/Akt, AMPK, and MAPK (Li et al., 2024)

Examples of support for favouring the 5a reductase pathway include: High therapeutic dose of zinc to move preference from 5a to 5b pathway Herbs such as Reishi, stinging nettle and saw palmetto Implement stress management such as daily breath work Ensure adequate vitamin D levels Increase flavonoids in the diet 3

Mfn 1/2 are located on the outer mitochondrial membrane, whereas Opa 1 is localized to the inner mitochondrial membrane (Figure 4)

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Zhang et al., 2017