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4.1 Clinical relevance of the CLP model The CLP model was selected for its unique ability to recapitulate core clinical features of SAE: polymicrobial sepsis, hippocampal neurodegeneration, and chronic cognitive impairment (Yin et al., 2023)

This is because copper is required for absorption of iron from the gastrointestinal tract and for release of iron from stores in macrophages in the body

This research was supported in part by JST SPRING Grant Number JPMJSP2110 to KShig, GteX Program Japan Grant Number JPMJGX23B4, the Institute for Fermentation, Osaka, the Itoku Community Development Foundation and the DAAD-Kyoto University Partnership Programme toward SDGs to start in 2024 to KShir, the DAAD-Kyoto University Partnership Programme toward SDGs to start in 2024 to FK, and JSPS KAKENHI, Grant Numbers 23K25056, 24H02120, and 25K03321 to HY

Peptide sind insbesondere in ihrer experimentellen Form kein Ersatz fr diese Grundlagen und sollten kritisch hinterfragt werden